Research Information System
Öztürk A. A. (Executive), Baghırova L.
Project Supported by Higher Education Institutions, 2021 - 2022
The way nanotechnology is used in the dermacosmetic/cosmetics industry in today's conditions is to transfer very small sized products such as nanoparticles produced in nanometric dimensions to the cosmetic content. In this way, nano-sized products, creams, gels, etc. By transferring to the products in the format, they can have the ability to act more actively in the penetration of the products into the dermis and epidermis, can be controlled optionally, and also the effectiveness of the dermacosmetic/cosmetic product can be increased. Dermocosmetic/Cosmetics manufacturers; It has begun to use nanoscale versions of cosmeceuticals for better UV protection, deeper skin penetration, long-lasting effects, and preventing stability problems. One of the reasons for choosing nanocosmetics; The nano-sized cosmetic materials have better properties such as color, solubility, permeability and spreadability, which will increase the consumer satisfaction compared to large particles. Vitamin A Palmitate (VAP) is a very important component of many important and various biological functions such as reproduction, embryological development, cellular differentiation, growth, immunity and vision. VAP functions mostly through nuclear retinoic acid receptors, retinoid X receptors, and peroxisome proliferator-activated receptors. Retinoids regulate the growth and differentiation of many cell types within the skin, and their deficiency leads to abnormal epithelial keratinization. In injured tissue, vitamin A stimulates the epidermal cycle, increases the re-epithelialization rate and improves the epithelial structure. VAP also has antioxidant and sunscreen effects. For this reason, VAP, a different dermacosmetic agent, was chosen as the model. A model drug carrier system will be selected after determining by physicochemical tests that VAP selected as the candidate active ingredient is compatible with polymer-based systems (PLGA-Chitosan). The optimum systems prepared will be characterized by particle size, polydispersity index, zeta potential, drug loading efficiency, release, release kinetics, solid state characterizations, antioxidant activity analyzes and the nanoparticle structure will be elucidated. It is planned to illuminate the wound healing activities of the newly designed VAP loaded nanoparticle formulations with experiments to be carried out in different cell lines and to compare with the pure active substance. With the nanoparticle formulations prepared within the scope of this thesis, it will provide higher antioxidant activity and therefore anti-aging effect compared to pure dermacosmetic material. With the formulations prepared, controlled release of the active ingredient in the formulation can be provided, the effect can be provided for a longer time instead of a short-term effect, the stability of the cosmetic active ingredient can be increased, undesirable effects such as bad odor caused by chemicals can be easily masked, the irritating feature of the cosmetic agent will be reduced and skin tolerance will be better. The fact that the formulations prepared also show wound healing properties will bring a new perspective to the dermacosmetic sector for anti-aging products. The formulations prepared will have the potential to be an intermediate product for the Dermacosmetic cosmetics industry