Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation

YURTTAŞ L., KAPLANCIKLI Z. A., TEMEL H. E., AKALIN ÇİFTÇİ G.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.42, sa.2, ss.169-180, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1515/tjb-2016-0207
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.169-180
  • Anahtar Kelimeler: Tetrazole, Hydrazone, Anticholinesterase, AChE, BuChE, Cytotoxicity, ACETYLCHOLINESTERASE INHIBITORS, CHOLINESTERASE-INHIBITORS, BIOLOGICAL-ACTIVITIES, ALZHEIMERS-DISEASE, DESIGN, CHEMISTRY, SUGARS, MOIETY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme inhibition activities and also cytotoxic properties on mouse embryonic fibroblast cells (NIH/3T3) were aimed in this work.