Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives

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TAY N. F., DURAN M., KAYAĞİL İ., YURTTAŞ L., GÖGER G., GÖGER F., ...More

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.58, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58
  • Publication Date: 2022
  • Doi Number: 10.1590/s2175-97902022e191026
  • Journal Name: BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: Triazole, Thiazole, Pyridine, Antimicrobial activity, Antioxidant activity, DPPH radical scavenging, 1,2,4-TRIAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, IN-VITRO, MOLECULAR DOCKING, HYBRID MOLECULES, LINKED BIS, ANTIFUNGAL, ANTITUMOR, ANTIBACTERIAL, AGENTS
  • Anadolu University Affiliated: Yes

Abstract

In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 mu g/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.