The way nanotechnology is used in the dermacosmetic / cosmetics industry under today's conditions is to transfer very small sized products such as nanoparticles produced in nanometric dimensions to the cosmetic content. Vitamin A palmitate is a very important component of many important and various biological functions such as reproduction, embryological development, cellular differentiation, growth, immunity and vision. Vitamin A palmitate also has antioxidant and sunscreen effects. This study describes the development and evaluation of poly (lactic-co-glycolic acid) (PLGA) nanoparticles for dermal delivery of Vitamin A palmitate. Structures of PLGA nanoparticles were elucidated by particle size, polydispersity index (PDI) and zeta potential. The particle size of the blank formulation was 181.77 nm whereas particle size of Vitamin A palmitate containing nanoparticles was 196.33 nm. The average PDI of all nanoparticle formulations were below 0.12 and all prepared nanoparticles had a negative zeta potential value. Particle size, PDI and zeta potential values of formulations prepared confirmed the successful preparation of Vitamin A palmitate into PLGA nanoparticles. Nanoparticle formulations seem to be promising for dermal delivery of Vitamin A palmitate for dermacosmetic use.

Keywords: PLGA, Vitamin A Plamitate, Nanoparticle, Dermacosmetic, Nanocosmetic.