Synthesis and antifungal activity of new hydrazide derivatives

Turan-Zitouni G., ALTINTOP M. D., ÖZDEMİR A., DEMİRCİ F., Abu Mohsen U., KAPLANCIKLI Z. A.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.28, no.6, pp.1211-1216, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.3109/14756366.2012.723208
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1211-1216
  • Keywords: Antifungal activity, hydrazide-hydrazone, tetrahydronaphthalene, anticandidal activity, CANDIDA, TERBINAFINE, HYDRAZONES, AGENTS
  • Anadolu University Affiliated: Yes

Abstract

In this study, nine new hydrazide derivatives were synthesized. The reaction of 2-[(5,6,7,8-tetrahydronaphthalen-2-yl) oxy]acetohydrazide with various benzaldehydes or acetophenones resulted in N'-substituted-2-[(5,6,7,8-tetrahydronaphthalen-2-yl) oxy] acetohydrazide derivatives. The structure elucidation of the synthesized and purified compounds was performed by using IR, H-1-NMR, and FAB(+)-MS spectral data and elemental analyses, respectively. Furthermore, the compounds were screened and evaluated for their antifungal activity against a panel of different human pathogenic Candida strains such as C. albicans, C. glabrata, C. utilis, C. tropicalis, C. krusei, C. zeylanoides and C. parapsilosis using agar diffusion and broth microdilution assays, respectively. Some of the tested compounds showed comparable antifungal activity (MIC = 0.0156->2 mg/mL) with ketoconazole.