Akademik Veri Yönetim Sistemi
European International Journal of Science and Technology, cilt.6, sa.5, ss.33-41, 2017 (Hakemli Dergi)
In this study, an economic, easy, basic, quick, sensitive and error-free reverse phase high performance liquid chromatography (RP-HPLC) modified method was developed for the determination of dexketoprofen trometamol. NUCLEODUR C18 (5.0 μ, 250 mm × 4.6 mm) was used as the stationary phase while acetonitrile-methanol (25:75 v/v) mixture was the mobile phase. Flow rate was 1 mL.min-1 and the detection wavelength was selected to be258 nm. The method developed was validated for precision, accuracy, specificity and linearity. Linearity was determined to be at a concentration range of 10-80 μg·mL-1.The method developed for dexketoprofen trometamol was decided to be precise due to RSD values of <2 %for repeatability and intermediate precision. Recovery of the method was satisfactory owing to <2 % RSD value. Conclusively, procedure proposed in this study can be used for routine, simultaneous and concurrent dexketoprofen trometamol determination.