Synthesis of new compounds bearing methyl sulfonyl pharmacophore as selective COX-2 inhibitor


Almarsoomi T., OSMANİYE D., SAĞLIK B. N., LEVENT S., Ghani U., ÖZKAY Y., ...Daha Fazla

Journal of Molecular Recognition, cilt.36, sa.7, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 7
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/jmr.3025
  • Dergi Adı: Journal of Molecular Recognition
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, MEDLINE, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: cyclooxygenase, dithiocarbamate, molecular docking, thiazole
  • Anadolu Üniversitesi Adresli: Evet

Özet

Cyclooxygenase, also known as prostaglandin H2 synthase (PGH2), is one of the most important enzymes in pharmacology because inhibition of COX is the mechanism of action of most nonsteroidal anti-inflammatory drugs. In this study, ten thiazole derivative compounds had synthesized. The analysis of the obtained compounds was performed by 1H NMR and 13C NMR methods. By this method, the obtained compounds could be elucidated. The inhibitory effect of the obtained compounds on cyclooxygenase (COX) enzymes was investigated. The encoded compounds 5a, 5b, and 5c were found to be the most potent compared to the reference compounds ibuprofen (IC50 = 5.589 ± 0.278 μM), celecoxib (IC50 = 0.132 ± 0.004 μM), and nimesulide (IC50 = 1.692 ± 0.077 μM)against COX-2 isoenzyme. The inhibitory activity of 5a, 5b, and 5c is approximate, but the 5a derivative proved to be the most active in the series with an IC50 value of 0.180 ± 0.002 μM. The most potent COXs inhibitor was 5a, which was further investigated for its potential binding mode by a molecular docking study. Compound 5a was found to be localized at the active site of the enzyme, like celecoxib, which has a remarkable effect on COXs enzymes.