Synthesis, characterization and antimicrobial activity of a Zn(II) complex with 1-(1H-benzoimidazol-2-yl)-ethanone thiosemicarbazone

POYRAZ M., SARI M., Gueney A., DEMİRCİ F., DEMİRAYAK Ş., ŞAHİN E.

JOURNAL OF COORDINATION CHEMISTRY, vol.61, no.20, pp.3276-3283, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 20
  • Publication Date: 2008
  • Doi Number: 10.1080/00958970802032678
  • Journal Name: JOURNAL OF COORDINATION CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3276-3283
  • Keywords: zinc complex, thiosemicarbazone complex, benzimidazole complex, crystal structure, antimicrobial activity, HELICOBACTER-PYLORI AGENTS, STRUCTURAL-CHARACTERIZATION, ANTITUMOR-ACTIVITY, ZINC-COMPLEXES, DERIVATIVES, ACID
  • Anadolu University Affiliated: Yes

Abstract

A new Zn(II) complex with 1-(1H-benzoimidazol-2-yl)-ethanone thiosemicarbazone [Zn(NO3)(H2O)(C10H11N5S)]NO3 was prepared and characterized by elemental analyses, FT-IR, H-1 NMR spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), and single-crystal X-ray diffraction analysis. The coordination geometry of the pentacoordinated zinc is a distorted square pyramid. The antimicrobial activity of the complex was evaluated using a broth micro-dilution method against a panel of human pathogenic Gram positive, Gram negative bacteria and the yeast Candida albicans. The best inhibitory effect was observed against Enterobacter aerogenes (MIC = 0.031 mg mL(-1)).