Capecitabine Induced Hand-Foot Syndrome: A Systematic Review of Case Reports

ARAS ATİK E., TECEN YÜCEL K., EKİNCİOĞLU A., GÜLLÜ İ.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.9, no.2, pp.178-191, 2019 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.33808/clinexphealthsci.469538
  • Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.178-191
  • Keywords: Capecitabine, hand-foot syndrome, mechanism, case reports, PALMAR-PLANTAR ERYTHRODYSESTHESIA, METASTATIC BREAST-CANCER, SQUAMOUS-CELL CARCINOMA, SKIN REACTION, ORAL CAPECITABINE, CLINICAL PRESENTATION, COMPLETE RESPONSE, LIVER METASTASES, LUNG METASTASES, TOPICAL HENNA
  • Anadolu University Affiliated: Yes

Abstract

Objective: Capecitabine, a prodrug of 5-fluorouracil, is currently used in the treatment of metastatic colorectal and breast cancers. The aim of this study was to review the pharmacological mechanisms, treatment strategies, and documented case reports of capecitabine-induced hand-foot syndrome (HFS).