Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives


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KAYA ÇAVUŞOĞLU B., ÖZKAY Y., TEMEL H. E., KAPLANCIKLI Z. A.

JOURNAL OF CHEMISTRY, vol.2016, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 2016
  • Publication Date: 2016
  • Doi Number: 10.1155/2016/5878410
  • Journal Name: JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anadolu University Affiliated: Yes

Abstract

Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N'-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin-1-yl]acetohydrazide with aromatic aldehydes. The chemical structures of the compounds were enlightened by FT-IR, H-1-NMR, C-13-NMR, and HRMS (ESI) spectral data. The inhibition potency of the compounds 3a-k against AChE and BuChE was measured and evaluated using a modification of Ellman's spectrophotometric method. Among the tested compounds, compound 3c was assigned to be the most active derivative. Galantamine was used as a standard drug .