Preparation of some pyrazoline derivatives and evaluation of their antifungal activities

ÖZDEMİR A., Turan-Zitouni G., KAPLANCIKLI Z. A., Revial G., DEMİRCİ F., Iscan G.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.25, no.4, pp.565-571, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.3109/14756360903373368
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.565-571
  • Keywords: Pyrazoline, antifungal activity, Candida spp., ANTIMICROBIAL ACTIVITIES, THIABENDAZOLE, ANTIBACTERIAL
  • Anadolu University Affiliated: Yes

Abstract

The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.