Cefdinir (CEF) is a semi synthetic third generation cephalosporin antibiotic used to treat bacterial infections. It has a short half-life of 1 to 2 hours with bioavailability of 20-25% [1]. CEF is a Biopharmaceutics Classification System (BCS) Class IV drug which means it has low solubility and low permeability. Even though it has marketed dosage forms, the challenge regarding treatment with CEF is that its solubility is much less than 1 mg/mL in water and highly dependent on pH. To overcome solubility problems, one of the solutions preferred is preparing solid dispersions (SDs). SDs can improve active pharmaceutical ingredient’s dissolution profile and bioavailability by increasing its aqueous solubility. To prepare SDs, some of the preferred polymers are polyvinyl pyrrolidone, polyvinyl alcohol and carboxymethyl cellulose. Polymers used to pre- pare solid dispersions must be inert and compatible with active pharmaceutical ingredient [2]. Kollicoat®Protect is copro- cessed blend of Polyvinyl alcohol-polyethylene glycol graft copolymer and polyvinyl alcohol. In this study, we aim to improve solubility of CEF by preparing solid dispersions using Kollicoat®Protect and evaluate its solubility and release properties.