New Procaspase Activating Compound (PAC-1) Like Molecules as Potent Antitumoral Agents Against Lung Cancer

YURTTAŞ L., Ozturk O., CANTÜRK Z.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.16, sa.6, ss.645-655, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1570180815666180926113040
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.645-655
  • Anahtar Kelimeler: Lung cancer, hydrazone, Procaspase Activating Compound (PAC-1), real-time cell analysis, physicochemical properties, antitumor activity, BENZOTHIAZOLE DERIVATIVES BEARING, CELL-DEATH, ANTIPROLIFERATIVE ACTIVITY, BIOLOGICAL EVALUATION, APOPTOSIS, ANTICANCER, GROWTH, PACLITAXEL, DISCOVERY, ANALOGS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: In this study, novel ortho-hydroxy N-acyl hydrazone moiety including compounds (3a-l) were designed, based on procaspase activating compound (PAC-1) which is a small molecule known with antitumor activity. The antitumor activity was evaluated on A549 (human lung cancer cell line) and CCD 19Lu (human lung normal cell line).