Molecular Imprinting Technology in Quartz Crystal Microbalance (QCM) Sensors

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EMİR DİLTEMİZ S., KEÇİLİ R., ERSÖZ A., Say R.

SENSORS, vol.17, no.3, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.3390/s17030454
  • Journal Name: SENSORS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: molecularly imprinted polymers (MIPs), quartz crystal microbalance (QCM), biosensors, biomolecular recognition, synthetic receptors, SOLID-PHASE EXTRACTION, RAPID DETECTION, SELECTIVE DETERMINATION, RECOGNITION ELEMENTS, POLYTHIOPHENE FILMS, MASS-SPECTROMETRY, CHEMICAL SENSORS, AU NANOPARTICLES, L-NICOTINE, POLYMER
  • Anadolu University Affiliated: Yes

Abstract

Molecularly imprinted polymers (MIPs) as artificial antibodies have received considerable scientific attention in the past years in the field of (bio)sensors since they have unique features that distinguish them from natural antibodies such as robustness, multiple binding sites, low cost, facile preparation and high stability under extreme operation conditions (higher pH and temperature values, etc.). On the other hand, the Quartz Crystal Microbalance (QCM) is an analytical tool based on the measurement of small mass changes on the sensor surface. QCM sensors are practical and convenient monitoring tools because of their specificity, sensitivity, high accuracy, stability and reproducibility. QCM devices are highly suitable for converting the recognition process achieved using MIP-based memories into a sensor signal. Therefore, the combination of a QCM and MIPs as synthetic receptors enhances the sensitivity through MIP process-based multiplexed binding sites using size, 3D-shape and chemical function having molecular memories of the prepared sensor system toward the target compound to be detected. This review aims to highlight and summarize the recent progress and studies in the field of (bio)sensor systems based on QCMs combined with molecular imprinting technology.