Eudragit® S 100 Nanoparticles Containing Ketoprofen Lysne: Preparation and Characterization


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Nur İlge Ç., Öztürk A. A., Yenilmez E.

12. Internation Symposium on Pharmaceutical Sciences (ISOPS 12), Ankara, Turkey, 26 - 29 June 2018, pp.315

  • Publication Type: Conference Paper / Full Text
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.315
  • Anadolu University Affiliated: Yes

Abstract

Ketoprofen lysinate (KL), the water soluble lysine salt of ketoprofen, is one of the most commonly used non-steroidal anti-inflammatory drug (NSAIDs) in the symptomatic treatment of various chronic inflammatory diseases. However, due to its short half-life of 1–2 h, a multiple dose regimen is required. Therefore, KL is an ideal candidate for the development of controlled drug delivery systems which are able to release the drug at a desired rate and in desired amount. Eudragit S 100 is an anionic copolymer based on methacrylic acid and methyl methacrylate. It is generally used for the formulation of transdermal patches, nanoparticles, microparticles, solid dispersions and spherical crystals. Eudragit S 100 has been used for various applications such as sustain release, bioavailability enhancement, improvement in micrometric properties. According to the aim of this study, KL-containing Eudragit S100 nanoparticles were prepared by double emultion solvent evaporation method.