Challenges, Progress and Promises of Impurities Annotation for LCMS-IT-TOF

ÖZCAN S., LEVENT S., CAN N. Ö.

CURRENT PHARMACEUTICAL ANALYSIS, vol.17, no.3, pp.437-449, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.2174/1573412916999200616125353
  • Journal Name: CURRENT PHARMACEUTICAL ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
  • Page Numbers: pp.437-449
  • Keywords: Mass prediction, impurity identification, LCMS-IT-TOF, mass spectrometry, time of flight, TIME-OF-FLIGHT, ION-TRAP-TIME, PERFORMANCE LIQUID-CHROMATOGRAPHY, RESOLUTION MASS-SPECTROMETRY, UNKNOWN IMPURITIES, SEPARATION, IDENTIFICATION, PESTICIDES, WATER, MS
  • Anadolu University Affiliated: Yes

Abstract

Analysis of pharmaceutical products, as well as their active and inactive ingredients, and identification and characterization of potential impurities originating from raw materials and manufacturing processes is of importance in the field, especially for further assessment of potential positive or negative effects on the human body. In addition to expected therapeutic effects, unfortunately, some unwanted or adverse effects were encountered in the past, resulting in dramatic cases sometimes. These challenges have been overcome with the use of sophisticated and high-end analytical techniques today by focusing on developing more efficient, more accurate, more accessible, and faster determination techniques.