Some urea and thiourea derivatives bearing 1,2,4-triazole ring and their anti-acetylcholinesterase activities

Abu Mohsen U., KAYMAKÇIOĞLU B., Celen A. O., KAPLANCIKLI Z. A.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.4, no.2, pp.85-89, 2014 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.5455/musbed.20140326030221
  • Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.85-89
  • Keywords: Urea, thiourea, 1,2,4-triazole, anti-acetylcholinesterase activity, CHOLINERGIC HYPOTHESIS, ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE, INHIBITION, DESIGN, DRUG
  • Anadolu University Affiliated: Yes

Abstract

Objective: Twenty different urea and thiourea derivatives were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) using a modification of Ellman's spectrophotometric method.