Novel Benzimidazole Derivatives: Cytotoxic and Apoptotic Properties on Lung Cancer Cell Line

YURTTAŞ L., AKALIN ÇİFTÇİ G., Akso M. O., DEMİRAYAK Ş.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.17, sa.10, ss.1227-1236, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/157018017999200513091613
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Sayfa Sayıları: ss.1227-1236
  • Anahtar Kelimeler: Benzimidazole, piperazine, anticancer activity, A549 lung cancer, cytotoxicity, apoptosis, ANTICANCER ACTIVITY, SAR
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Benzimidazole derivatives are privileged molecules known to have a wide variety of biological activities. In medicinal chemistry, due to the ring's structural similarity to nucleotides, its derivatives were investigated as new chemotherapeutic agents. Our research group have been studying 1,2-disubstituted benzimidazoles, including thiocarbamoyl group and their potential anticancer activity. Based on previous findings, we synthesized novel 1-[2-(4-substituted phenyl-2-oxoethyl)]-2-[(2/3/4-substituted phenylpiperidin-1-yl)thiocarbamoyl]benzimidazole derivatives (3a-o).