CE determination of droperidol in tablets and human serum

Tuncel M., Dogrukol-Ak D., Yeniceli D., USLU B., Dogan B.

CHROMATOGRAPHIA, no.9-10, pp.507-511, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2006
  • Doi Number: 10.1365/s10337-006-0775-0
  • Journal Name: CHROMATOGRAPHIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.507-511
  • Keywords: capillary electrophoresis, human serum, droperidol, PERFORMANCE LIQUID-CHROMATOGRAPHY, SPECTROPHOTOMETRIC DETERMINATION, CAPILLARY-ELECTROPHORESIS, BUTYROPHENONES, DEGRADATION, PLASMA, HALOPERIDOL, BLOOD
  • Anadolu University Affiliated: Yes

Abstract

A capillary electrophoretic method was described for the determination of droperidol in pharmaceutical tablets and human serum. Droperidol and internal standard, lansoprazole, were separated on an uncoated fused-silica capillary using a run buffer containing borate (10 mM; pH 9.3) and aqueous methanol (20%, v/v). The signals were detected at 210 nm. The migration times for droperidol and internal standard were 2.1 and 2.9 min, respectively. The method has been validated in the range of 2.2 x 10(-5) - 7.8 x 10(-5) M and applied to both tablets and human serum with good repeatability and no interference.