Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles

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YURTTAŞ L., Şahin Z., Er S., Demirayak Ş.

Acta Pharmaceutica Sciencia, cilt.54, sa.1, ss.43-52, 2016 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.23893/1307-2080.aps.0544
  • Dergi Adı: Acta Pharmaceutica Sciencia
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.43-52
  • Anahtar Kelimeler: Antibacterial activity, Nitrofurans, Nitrofurazone, Thiazole
  • Anadolu Üniversitesi Adresli: Evet

Özet

© 2016, University of Istanbul. All rights reserved.In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial activity of the title compounds were screened against five Gram positive bacteria B. cereus, E. faecalis, S. aureus, S. epidermidis, L. monocytogenes and two Gram negative bacteria E. coli and S. typhi. MIC and MBC were calculated and compared to standard drug nitrofurazone. Compounds bearing pyridine moiety (2d-e) exhibited significant antimicrobial activity which could be evaluated as new, potent antibacterial agents.