Synthesis of Some Imidazo[1,2-a]pyrazine Derivatives and Evaluation of Their Antinociceptive Activity

Turan-Zitouni G., YURTTAŞ L., ÖZDEMİR A., KAPLANCIKLI Z. A., Masquefa C.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.6, no.1, pp.9-13, 2016 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.5152/clinexphealthsci.2016.024
  • Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.9-13
  • Keywords: Antinociceptive, hydrazone, imidazopyrazine, hot plate, writhing test
  • Anadolu University Affiliated: Yes

Abstract

Objective: The imidazopyrazine ring is a biologically active heterocyclic ring. Many hydrazide-hydrazone-possessing compounds have been reported to have interesting bioactivity, such as antibacterial, antifungal, anticonvulsant, anti-inflammatory, antituberculosis, and analgesic activities. In particular, aroyl hydrazides/hydrazone-containing hetero-rings, such as indole, pyridine, and imidazo[2,1-b]pyridine, and imidazo[1,2-a]pyrazine, have attracted special attention. We designed and synthesized N-(4-substitutedbenzylidene) imidazo[1,2-a]pyrazine-2-carbohydrazide (2a-j) derivatives using the two aforementioned pharmacophoric units based on the synthetic procedure indicated in our previous study.