A Novel HPLC Method for Simultaneous Determination of Methyl, Ethyl, n-propyl, Isopropyl, n-butyl, Isobutyl and Benzyl Paraben in Pharmaceuticals and Cosmetics

ÖZCAN S., LEVENT S., CAN N. Ö., Kozanli M.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol.24, no.3, pp.352-365, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.2174/1386207323999200728121657
  • Journal Name: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.352-365
  • Keywords: Core-shell column, cosmetic product, isomer separation, LC-DAD, pharmaceutical product, P-hydroxybenzoic acid derivatives, ASSISTED EMULSIFICATION MICROEXTRACTION, LIQUID-LIQUID MICROEXTRACTION, SOLID-PHASE DISPERSION, ENDOCRINE DISRUPTORS, SAMPLE PREPARATION, SAFETY ASSESSMENT, HUMAN EXPOSURE, CHROMATOGRAPHY, PRESERVATIVES, PRODUCTS
  • Anadolu University Affiliated: Yes

Abstract

Introduction: The alkyl esters of p-hydroxybenzoic acid at the C-4 position, "the parabens," including methyl, ethyl, propyl, and butyl, are widely used as antimicrobial preservatives in foods, cosmetics, and pharmaceuticals. Official regulations on the use of these compounds make their analysis essential for the estimation of their exposure.