ANATOLIAN JOURNAL OF CARDIOLOGY, vol.17, no.1, pp.8-17, 2017 (SCI-Expanded)
Article / Article
ANATOLIAN JOURNAL OF CARDIOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Pulmonary hypertension, vascular remodeling, monocrotaline, everolimus, alagebrium, matrix metalloproteinases, ARTERIAL-HYPERTENSION, EXTRACELLULAR-MATRIX, HEART, EXPRESSION, INFLAMMATION, INHIBITORS, MODEL
Anadolu University Affiliated:
Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary hypertension (PH) model in rats. In particular, the inter-relationships between PH and matrix metalloproteinases (MMPs) were investigated.