Copy For Citation
YURTTAŞ L., KAPLANCIKLI Z. A., Gorgulu-Kahyaoglu S.
LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.8, pp.910-917, 2017 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
14
Issue:
8
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Publication Date:
2017
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Doi Number:
10.2174/1570180814666161207163450
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Journal Name:
LETTERS IN DRUG DESIGN & DISCOVERY
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.910-917
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Keywords:
Antiproliferative, apoptosis, cytotoxicity, hydrazone, piperazine, biological activities, PROCASPASE-ACTIVATING COMPOUND, ANNEXIN-V, BENZIMIDAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, AGENTS
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Anadolu University Affiliated:
Yes
Abstract
Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis in some tumour models.