Synthesis and cytotoxic and analgesic activities of some 1,5-diaryl-3-ethoxycarbonylpyrrole derivatives

DEMİRAYAK Ş., Beis R., KARABURUN A. Ç., Kayagil I., Incesu Z., Ucucu U.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, sa.1, ss.113-118, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/14756360500472845
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.113-118
  • Anahtar Kelimeler: diarylpyrrole, cytotoxicity, analgesic activity, SELECTIVE CYCLOOXYGENASE-2 INHIBITORS, COX-2 INHIBITORS, BIOLOGICAL EVALUATION, 2,3-DIARYLTHIOPHENES, IDENTIFICATION, POTENT, SERIES
  • Anadolu Üniversitesi Adresli: Evet

Özet

Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. The cytotoxicity of the compounds was tested and all compounds, except for compound 2 h, showed a time-dependent increase in cytotoxic activity. Analgesic activities of the compounds were determined by using the tail-flick and tail-immersion methods; some of the compounds showed potent analgesic activity.