Synthesis and antimicrobial activity of 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives

ÖZDEMİR A., Turan-Zitouni G., KAPLANCIKLI Z. A., Revial G., Guven K.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.42, no.3, pp.403-409, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.ejmech.2006.10.001
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.403-409
  • Keywords: 2-pyrazoline, thiazole, antimicrobial activity, BICYCLIC PYRAZOLIDINONES, ANTIBACTERIAL, ANTIFUNGAL, PYRAZOLINES
  • Anadolu University Affiliated: Yes

Abstract

Several 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting substituted 3-(2-thienyl)-5-aryl-lthiocarbarnoyl-2-pyrazolines with phenacyl bromides in ethanol. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR, and EIMS spectral data. Their antimicrobial activities against Escherichia coli (NRPL B-3704), Staphylococcus aureus (NRLL B-767), Salmonella typhinturium (NRRL B-4420), Bacillus cereus (NRRL B-3711), Streptococcus faecalis (NRRL B-14617), Aeromonas hydrophila (Ankara Uni. Fac. of Veterinary), Candida albicans and Candida glabrata (isolates obtained from Osmangazi Uni. Fac. of Medicine) were investigated. A significant level of activity was observed. (c) 2006 Elsevier Masson SAS. All rights reserved.