In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells

YURTTAŞ L., Demirayak Ş., ILGIN S., Atli Ö.

Bioorganic and Medicinal Chemistry, cilt.22, sa.22, ss.6313-6323, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 22
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.bmc.2014.10.002
  • Dergi Adı: Bioorganic and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.6313-6323
  • Anahtar Kelimeler: 1,2,4-Triazine, Piperazine amide, Breast cancer, Antiproliferative activity, Apoptosis, XTT method, ANTICANCER ACTIVITY, AGENTS, ANALOGS, SYSTEMS, THIOGLYCOSIDE, APOPTOSIS
  • Anadolu Üniversitesi Adresli: Evet

Özet

© 2014 Elsevier Ltd. All rights reserved.A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis(4-subtituted phenyl)-1,2,4-triazin-3-yl)piperazin-1-yl]-2-[4-(3-substituted phenyl)piperazin-1-yl]ethanone derivative (1-32) compounds were synthesized by a four step synthetic procedure. The activity studies were evaluated using XTT method, BrdU method and flow cytometric analysis on MCF-7 breast cancer cells and NIH/3T3 (mouse embryonic fibroblast cells) healthy cells. Compounds 5 with 3-chlorophenyl and compound 7 with 4-chlorophenyl substitutions were found to be promising antiproliferative agents comparing with an effective anticancer drug, cisplatin.