Superparamagnetic nanotraps containing MIP based mimic lipase for biotransformations uses

KEÇİLİ R., Ozcan A. A., ERSÖZ A., HÜR D., DENİZLİ A., Say R.

JOURNAL OF NANOPARTICLE RESEARCH, vol.13, no.5, pp.2073-2079, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1007/s11051-010-9962-x
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2073-2079
  • Keywords: Biotransformations, Molecularly imprinted polymer (MIP), Nanotraps, Lipase, Nanobiotechnology, MAGNETIC NANOPARTICLES, MEDIATED SYNTHESIS, POLYMERS, RECOGNITION, CATALYSIS, SURFACES, BINDING, SITES
  • Anadolu University Affiliated: Yes


The nanoparticle comprises a superparamagnetic iron oxide nanoparticle core conjugated with trimethoxylsilyl propylmethacrylate (TMSPM) and methacryloylamido serine (MASE), methacryloylamido histidine (MAH), methacryloylamido glutamic acid (MAGA) monomers, and p-nitrophenyl palmitate (p-NPP) which is a substrate of lipase as a template molecule, which enables the creation of lipase active region. The resulting hybrid superparamagnetic nanotraps are magnetically separable, highly active, and stable under harsh conditions. In this study, the advantages of high selectivity of molecular imprinting technique have used to get mimic lipase for the synthesis of methyl jasmonate and methyl oleate.