Synthesis and Evaluation of Heterocycles Based Chalcone Derivatives as Anti-proliferative Agents

KAYA ÇAVUŞOĞLU B., ATLI EKLİOĞLU Ö., Gormus G., ÖZKAY Y., KAPLANCIKLI Z. A.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.18, no.7, pp.1044-1053, 2018 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 18 Issue: 7
  • Publication Date: 2018
  • Doi Number: 10.2174/1871520618666180105163657
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1044-1053
  • Keywords: Chalcone, antiproliferative activity, cytotoxicity, apoptotic pathway, derivatives, heterocycles, VITRO ANTITUMOR-ACTIVITY, ANTICANCER ACTIVITIES, APOPTOSIS, CYTOTOXICITY, REACTIVITY, PARADIGM, ANALOGS, DESIGN
  • Anadolu University Affiliated: Yes

Abstract

Background: The lack of selectivity and development of drug-resistance encourage researchers to search for novel, more efficient and multi-targeted agents with less toxicity.