Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles

ÖZKAY Y., TUNALI Y., KARACA H., IŞIKDAĞ İ.

ARCHIV DER PHARMAZIE, vol.344, no.4, pp.264-271, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 344 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.1002/ardp.201000172
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.264-271
  • Keywords: Antimicrobial, (Benz)azolylthio, Benzimidazole, Brine-Shrimp lethality assay, Candida species, ANTIFUNGAL ACTIVITY, POTENT ACTIVITY, DERIVATIVES, ANTIBACTERIAL, THIABENDAZOLE, IMIDAZOLE
  • Anadolu University Affiliated: Yes

Abstract

In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds (5a-5i) were confirmed by their IR, H-1-NMR, ES-MS spectral data, and elemental analyses. The synthesized compounds (5a-5i) exhibited poor activity against bacterial strains. On the other hand, antifungal activity of the compounds against Candida species was very significant. Brine-Shrimp lethality assay was performed for determination of toxicity of the compounds. Compounds 5a, 5c, and 5d were evaluated as non-toxic in addition to their attractive antifungal activity. However, the other compounds (5b, e-i) in the series showed toxicity to different extents.