Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.2, pp.169-180, 2017 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 42 Issue: 2
- Publication Date: 2017
- Doi Number: 10.1515/tjb-2016-0207
- Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.169-180
- Keywords: Tetrazole, Hydrazone, Anticholinesterase, AChE, BuChE, Cytotoxicity, ACETYLCHOLINESTERASE INHIBITORS, CHOLINESTERASE-INHIBITORS, BIOLOGICAL-ACTIVITIES, ALZHEIMERS-DISEASE, DESIGN, CHEMISTRY, SUGARS, MOIETY
- Anadolu University Affiliated: Yes
Abstract
Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme inhibition activities and also cytotoxic properties on mouse embryonic fibroblast cells (NIH/3T3) were aimed in this work.