Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation

YURTTAŞ L., KAPLANCIKLI Z. A., TEMEL H. E., AKALIN ÇİFTÇİ G.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.2, pp.169-180, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1515/tjb-2016-0207
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.169-180
  • Keywords: Tetrazole, Hydrazone, Anticholinesterase, AChE, BuChE, Cytotoxicity, ACETYLCHOLINESTERASE INHIBITORS, CHOLINESTERASE-INHIBITORS, BIOLOGICAL-ACTIVITIES, ALZHEIMERS-DISEASE, DESIGN, CHEMISTRY, SUGARS, MOIETY
  • Anadolu University Affiliated: Yes

Abstract

Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme inhibition activities and also cytotoxic properties on mouse embryonic fibroblast cells (NIH/3T3) were aimed in this work.