Analysis of peripheral blood lymphocyte phenotypes and Th1/Th2 cytokines profile in the systemic immune responses of Helicobacter pylori infected individuals
Microbiology and Immunology, cilt.52, sa.11, ss.531-538, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52 Sayı: 11
- Basım Tarihi: 2008
- Doi Numarası: 10.1111/j.1348-0421.2008.00066.x
- Dergi Adı: Microbiology and Immunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.531-538
- Anahtar Kelimeler: Cytokines, Gamma delta T cells, Helicobacter pylori, Immunophenotyping
- Anadolu Üniversitesi Adresli: Hayır
Özet
H. pylori elicits specific humoral and cellular immuneresponses inthemucosal immune system. However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls. While αβ TCR+ lymphocytes and their phenotype analysis were not significantly different to those of healthy controls, the percentage of pan γθ TCR+ lymphocytes was up to 2.4 times greater in the H. pylori positive group then in healthy controls. Furthermore, significant increases in IL-10 concentrations in serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2 type immune response. The correlation between phenotype and type of T cell response in the peripheral blood during H. pylori infection is discussed. © 2008 The Societies and Blackwell Publishing Asia Pty Ltd.