Relation Between Ceramidase Inhibition And Cytotoxicity In DrugResistant Breast Cancer Cells

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Kuş G.

5TH INTERNATIONAL CONFERENCE ON PIONEER AND INNOVATIVE STUDIES ICPIS 2026, Konya, Turkey, 8 - 09 June 2026, pp.86, (Summary Text)

  • Publication Type: Conference Paper / Summary Text
  • City: Konya
  • Country: Turkey
  • Page Numbers: pp.86
  • Anadolu University Affiliated: Yes

Abstract

The most common type of cancer worldwide in women, is breast cancer, that negatively impacting the health of approximately 2.1 million poeple each year. Recently, with the increasing incidence of cancer and the ongoing search for more effective treatment methods, research in this field has become increasingly important. Recent cancer studies focus on new biomarkers, pathways, and potential therapeutic agents for breast cancer and cancer have revealed a link between sphingolipid metabolism and cancer. Sphingolipids are lipids belonging to the lipid family that regulate membrane fluidity and are part of a bilayer of membrane lipid structures. The metabolites of sphingolipids have regulatory roles in cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis, and cell signalling. Furthermore, increased intracellular ceramide levels in response to various stress stimuli lead to apoptosis. Disruption of this mechanism increases the survival rate in cancer cells and can lead to the development of resistance to cancer treatment. Therefore, targeting ceramide metabolism is considered a novel approach in cancer therapy. Concequently, this reserach investigated the cytotoxic effects of ceranib-2, an inhibitor of ceramidases, on breast cancer using bortezomib-resistant and nonresistant cell lines. The results showed the potential of ceramidase inhibition for increasing cytotoxicity in breast cancer cells. Therefore further investigations are recommended to uncover the cellular impacts to overcome drug-resistance and to develop a therapeutic for targetted breast cancer therapy. This study was supported by Project Unit of Anadolu University under the Project Number FBA-2023- 86. The authors thank to Anadolu University for their supports. Keywords – Breast cancer, Sphingolipids, Ceramidases, Cytotoxicity, Cell death.