Determination of the Physicochemical Properties of Piroxicam

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ÇELEBİER M., NENNİ M., KAPLAN O., Akgeyik E., KAYNAK M. S., ŞAHİN S.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, sa.5, ss.535-541, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2019.82335
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.535-541
  • Anahtar Kelimeler: Piroxicam, physicochemical properties, pKa, Log P, Log D, Log kw, WATER PARTITION-COEFFICIENTS, ACID DISSOCIATION-CONSTANTS, POTENTIOMETRIC DETERMINATION, PK(A) DETERMINATION, GRADIENT HPLC, PKA VALUES, RP-HPLC, LIPOPHILICITY, DISSOLUTION, VALIDATION
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objectives: The aim of this study was to determine the acid dissociation constant (pKa) of piroxicam using high performance liquid chromatography (HPLC) and ultraviolet-visible (UV-Vis) spectrophotometry, and to determine the partition coefficient (Log P), distribution coefficient (Log D), and "Log kw" values of piroxicam using HPLC.