Determination of the Physicochemical Properties of Piroxicam
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.5, pp.535-541, 2020 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 17 Issue: 5
- Publication Date: 2020
- Doi Number: 10.4274/tjps.galenos.2019.82335
- Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.535-541
- Keywords: Piroxicam, physicochemical properties, pKa, Log P, Log D, Log kw, WATER PARTITION-COEFFICIENTS, ACID DISSOCIATION-CONSTANTS, POTENTIOMETRIC DETERMINATION, PK(A) DETERMINATION, GRADIENT HPLC, PKA VALUES, RP-HPLC, LIPOPHILICITY, DISSOLUTION, VALIDATION
- Open Archive Collection: AVESIS Open Access Collection
- Anadolu University Affiliated: Yes
Abstract
Objectives: The aim of this study was to determine the acid dissociation constant (pKa) of piroxicam using high performance liquid chromatography (HPLC) and ultraviolet-visible (UV-Vis) spectrophotometry, and to determine the partition coefficient (Log P), distribution coefficient (Log D), and "Log kw" values of piroxicam using HPLC.