Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes

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ÖZEK G., Yur S., GÖGER F., ÖZEK T., Andjelkovic B., Godjevac D., ...Daha Fazla

CHEMISTRY & BIODIVERSITY, cilt.16, sa.4, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/cbdv.201800672
  • Dergi Adı: CHEMISTRY & BIODIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Heracleum species, furanocoumarins, antioxidants, acetylcholinesterase inhibition, antidiabetic activity, ESSENTIAL OIL, SPHONDYLIUM, PLATYTAENIUM, COUMARINS, BOISS.
  • Anadolu Üniversitesi Adresli: Evet

Özet

Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied for their furanocoumarin content antioxidant potential and acetylcholinesterase and -amylase inhibitory activities. Quantification of the furanocoumarins was performed by H-1-NMR. Pimpinellin was found to be the main component in the roots of all studied species. Bergapten and imperatorin were the major compounds in the fruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H. ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavenging activity and TEAC (IC50 0.58mg/mL and 1.83mm, respectively). The root extracts of H. verticillatum and H. angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34mg/mL, respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7) towards -amylase.