Betulenols from Betula species

Demirci B., Baser K., ÖZEK T., DEMİRCİ F.

PLANTA MEDICA, vol.66, no.5, pp.490-493, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Letter
  • Volume: 66 Issue: 5
  • Publication Date: 2000
  • Doi Number: 10.1055/s-2000-8591
  • Journal Name: PLANTA MEDICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.490-493
  • Anadolu University Affiliated: Yes


The essential oils from buds of five Betula species growing in Turkey were investigated by CC-MS. A major component in the essential oils was shown to be 14-hydroxy-beta-caryophyllene (6). The structure of beta-betulenal (12) which was isolated from Betula essential oils was also confirmed by synthesis. Chemical reactions yielded 14-acetoxy-beta-caryophyllene (15), 14-hydroxy-isocaryophyllene (10) and its acetate (14), giving evidence to the natural occurrence in Betula species of the formerly known alpha-betulenol acetate (3), beta-betulenol (2) and beta-betulenol acetate (4), respectively. Compounds 6, 9, 10, 12, and 15 were evaluated for antimicrobial activity.