A preliminary investigation of anticancer activity of novel benzothiazole derivatives against A549 lung carcinoma cell line

YURTTAŞ L., KAYA ÇAVUŞOĞLU B., Sever A., AKALIN ÇİFTÇİ G.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.5, pp.535-544, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1515/tjb-2017-0015
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.535-544
  • Keywords: Benzothiazole, Synthesis, Lung cancer, Cytotoxicity, Apoptosis, ANTITUMOR BENZOTHIAZOLES, IN-VITRO, BIOLOGICAL-PROPERTIES, CANCER, SURVIVAL, 2-(4-AMINOPHENYL)BENZOTHIAZOLES, CYTOTOXICITY, POTENT, AGENTS, VIVO
  • Anadolu University Affiliated: Yes

Abstract

Objective(s): In this study, it was aimed to synthesize new chemotherapeutic agents based on known antiproliferative properties of benzothiazol-2-amine moiety. The antitumor activity of the newly synthesized compounds was determined against A549 lung cancer cell lines.