Design and Efficient Synthesis of Novel 4,5-Dimethylthiazole-Hydrazone Derivatives and their Anticancer Activity

Evren A. E., YURTTAŞ L., Ekselli B., Aksoy O., AKALIN ÇİFTÇİ G.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.18, sa.4, ss.372-386, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1570180817999201022192937
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
  • Sayfa Sayıları: ss.372-386
  • Anahtar Kelimeler: Thiazole, hydrazone, A549, C6, apoptosis, anticancer activity, BIOLOGICAL EVALUATION, THIAZOLE DERIVATIVES, LUNG-CANCER, PYRIDINE-DERIVATIVES, DRUG-RESISTANCE, IN-SILICO, CYTOTOXICITY, DASATINIB, ANALOGS, GLIOMA
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Recently, researchers have been warning about the increased mortality of the various cancer types. Also, the lung adenocarcinoma and the glioma types are burning issues for world's health due to late or wrong diagnosis and/or insufficient treatment methods. For this purpose, our research group designed and synthesized novel 4,5-dimethyl thiazole-hydrazone derivatives which were tested against cancer and normal cell lines to understand the structure-activity relationship (SAR).