Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp siculum

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Rosselli S., Bruno M., Raimondo F. M., Spadaro V., Varol M., Koparal A. T., ...More

MOLECULES, vol.17, no.7, pp.8186-8195, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 7
  • Publication Date: 2012
  • Doi Number: 10.3390/molecules17078186
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.8186-8195
  • Keywords: Tanacetum vulgare, sesquiterpenes, eudesmanolides, cytotoxic activity, SESQUITERPENE LACTONES, IN-VITRO, AERIAL PARTS, DERIVATIVES, CELLS, L., PARTHENOLIDE, PRAETERITUM, INHIBITION, ANTICANCER
  • Anadolu University Affiliated: Yes


A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.