Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity

Turan-Zitouni G., Chevallet P., KILIÇ F. S., Erol K.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.35, no.6, pp.635-641, 2000 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2000
  • Doi Number: 10.1016/s0223-5234(00)00152-5
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.635-641
  • Keywords: thiazol, pyrazoline, thiazolyl-pyrazoline, chalcone, hypotensive activity, MONOAMINE-OXIDASE, ANTICONVULSANT
  • Anadolu University Affiliated: No

Abstract

Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds were performed by IR, H-1-NMR and Mass spectral data and elemental analyses. The hypotensive activities of 13 compounds were evaluated by using the tail-cuff method. All examined compounds showed appreciable hypotensive activities. Clonidine was used as reference substance in the pharmacological evaluation. (C) 2000 Editions scientifiques et medicales Elsevier SAS.