Determination of nabumetone in pharmaceutical formulation by flow injection analysis (FIA) with UV-detection

CAN N. Ö., Tuncel M., Aboul-Enein H.

PHARMAZIE, vol.58, no.1, pp.22-24, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1
  • Publication Date: 2003
  • Journal Name: PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.22-24
  • Anadolu University Affiliated: Yes

Abstract

A precise and accurate FIA method for the quantification of nabumetone (NAB) in pharmaceuticals is described. The best suitable carrier solvent system consisted of ethanol: water (30: 70 v/v). Sample solution (4.7 x 10(-6) M NAB) was prepared in this solvent and injected to the instrumental system at a flow rate of 1.2 ml (.) min(-1). The signals were detected by a UV detector at 228.8 nm. The calibration curves of NAB was linear in the concentration range of 1.4 x 10(-6) M-2.8 x 10(-5) M. The intra- and inter-assay precision were less than 2.6%. The method exhibited a good linearity with the correlation coefficients. The LOD and LOQ values were found to be 4.4 x 10(-7) and 1.3 x 10(-6) M, respectively. The effects of the tablet excipients were insignificant at the 95% probability level. The calculated tablet content was 99% which is agreement with the ranges stated by pharmacopoeias.