EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.44, no.6, pp.2606-2610, 2009 (SCI-Expanded)
Article / Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
Pyrazoline, Benzoxazole, Benzimidazole, Hot plate, Writhing test, Rota-Rod, NITRIC-OXIDE SYNTHASE, PHARMACOLOGICAL-PROPERTIES, ANTIINFLAMMATORY AGENTS, MICE, CYCLOOXYGENASE-2, INHIBITION, EXTRACT, POTENT, BASES, ACID
Anadolu University Affiliated:
In the present study, some pyrazoline derivatives were synthesized to investigate their potential antinociceptive activities. 1-[(Benzoxazole/benzimidazole-2-yl)thioacetyl]pyrazoline derivatives were obtained by reacting 3,5-diaryl-1-(2-chloroacetyl)pyrazolines with 2-marcaptobenzoxazole/benzimidazole. The chemical structures of the compounds were elucidated by IR, H-1 NMR and FAB(+)-MS spectral data and Elemental Analyses.