LETTERS IN DRUG DESIGN & DISCOVERY, vol.13, no.6, pp.563-569, 2016 (SCI-Expanded)
Article / Article
LETTERS IN DRUG DESIGN & DISCOVERY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Antitumor activity, aurone, benzofuranone, chalcone, cytotoxic activity, CANCER-CELL LINES, BIOLOGICAL EVALUATION, CHALCONE DERIVATIVES, ANTICANCER ACTIVITY, AURONES, INHIBITORS, AGENTS, DISCOVERY
Anadolu University Affiliated:
The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4-chlorobenzylidene)- 6-[2-(4-methoxyphenyl)-2-oxoethoxy] benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines.