Formulation and Evaluation of Spray Dried Chitosan Nanoparticles of Levocetirizine Dihydrochloride for Antihistaminic Treatment


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Yurtdaş Kırımlıoğlu G., Öztürk A. A.

12. International Symposium on Pharmaceutical Sciences (ISOPS 12), Ankara, Turkey, 26 - 29 June 2018, pp.302

  • Publication Type: Conference Paper / Full Text
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.302
  • Anadolu University Affiliated: Yes

Abstract

Levocetirizine dihydrochloride (LCD) is a third generation non-sedative antihistamine. LCD works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to receptors. In addition, it is an important drug in the treatment of allergies and idiopathic urticaria (1). Chitosan (CS) is a natural biodegradable and biocompatible polysaccharide (2). In this study; LCD loaded CS nanoparticles prepared by spray-drying method for extended antihistaminic delivery of oral use was aimed in this study.