Formulation and Evaluation of Spray Dried Chitosan Nanoparticles of Levocetirizine Dihydrochloride for Antihistaminic Treatment

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Yurtdaş Kırımlıoğlu G., Öztürk A. A.

12. International Symposium on Pharmaceutical Sciences (ISOPS 12), Ankara, Türkiye, 26 - 29 Haziran 2018, ss.302

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.302
  • Anadolu Üniversitesi Adresli: Evet

Özet

Levocetirizine dihydrochloride (LCD) is a third generation non-sedative antihistamine. LCD works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to receptors. In addition, it is an important drug in the treatment of allergies and idiopathic urticaria (1). Chitosan (CS) is a natural biodegradable and biocompatible polysaccharide (2). In this study; LCD loaded CS nanoparticles prepared by spray-drying method for extended antihistaminic delivery of oral use was aimed in this study.