Chemical characterization, antioxidant activity, a-amylase and acetylcholinesterase inhibitory potential of Angelica pancicii Vandas ex Velen

Trendafilova A., ÖZEK G., Yurb S., GÖGER F., ÖZEK T., Rangelov M., ...Daha Fazla

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS, cilt.21, sa.4, ss.418-430, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.37360/blacpma.22.21.4.25
  • Dergi Adı: BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Fuente Academica Plus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.418-430
  • Anahtar Kelimeler: Angelica pancicii, Essential oils, Coumarins, Antioxidant activity, a-amylase inhibiton, Acethylcholinesterase inhibition, NATURAL-PRODUCTS, ESSENTIAL OILS, IN-VITRO, COUMARINS, CHOLINESTERASE, EXTRACT, ARCHANGELICA, FRUITS, PLANTS, ROOTS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Comparative study GC-FID/MS of essential oils of fruits, leaves and roots of the endemic plant Angelica pancicii Vandas ex Velen. revealed a significant difference in their chemical composition. The enantiomeric purity of the main component in the fruit oil (+)-(3-phellandrene was also confirmed. In addition, imperatorin, isoimperatorin, oxypeucedanin, oxypeucedanin hydrate, angeloylpangelin and umbelliprenin were isolated from the fruit hexane extract. The content of these coumarins in the hexane extracts from different plant parts was further determined by HPLC. The essential oils and hexane extracts were assessed for their antioxidant potential and inhibitory effect towards a-amylase and acetylcholinesterase enzymes. The fruit and leaf essential oils (> 80%) as well as the fruit hexane extract (> 62%) significantly inhibited acetylcholinesterase enzyme. Distinguish free radical scavenging properties were detected for the leaf (Inh. 95.0 +/- 2.2 %) and the root (Inh. 66.0 +/- 2.4 %) extracts.