THE FACTORS EFFECTING COMPLEMENT ACTIVATION IN OPEN-HEART-SURGERY

ASLAN R., TUNERIR B., DERNEK S., KURAL T., SEVIN B., KAKLIKKAYA I., ...Daha Fazla

JOURNAL OF CARDIOVASCULAR SURGERY, cilt.33, sa.6, ss.754-760, 1992 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 6
  • Basım Tarihi: 1992
  • Dergi Adı: JOURNAL OF CARDIOVASCULAR SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.754-760
  • Anahtar Kelimeler: COMPLEMENT ACTIVATION, CARDIOPULMONARY BYPASS, PULMONARY NEUTROPHIL TRAPPING
  • Anadolu Üniversitesi Adresli: Hayır

Özet

The activation of the complement system was investigated in 10 patients with rheumatic valve disease having heart surgery. The C3c, C4, leukocyte count and polymorphonuclear neutrophil count were determined in the blood samples taken before anaesthesia, after anaesthesia, 10 minutes after protamine administration and after the closure of the skin incision. In addition, atrial blood samples were taken after the release of the cross-clamp and pulmonary neutrophil trapping was investigated. In this study C3c and C4 consumption was found to take place after 30 minutes of CPB (cardiopulmonary bypass) and 10 minutes after protamine administration; the affects of anaesthesia and heparin were not significant.