Effects of reciprocal interactions between various dietary fats and circadian phases on postprandial hyperlipidemia in rats

Satılmış B., Kayhan B., Güldür T.

Biological Rhythm Research, vol.49, no.1, pp.77-91, 2018 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1080/09291016.2017.1333199
  • Journal Name: Biological Rhythm Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.77-91
  • Keywords: Chylomicron, Circadian rhythms, Dietary fats, Hyperlipidemia, Microsomal triglyceride transfer protein
  • Anadolu University Affiliated: No


© 2017 Informa UK Limited, trading as Taylor & Francis Group.Expression levels of various intestinal proteins involved in postprandial lipoprotein assembly as well as plasma triglyceride concentration exhibit daily oscillations indicating circadian control. The length of the carbon chain and degree and position of unsaturation of fatty acids influence triglyceride secretion by the enterocytes. To this end, effects of reciprocal interactions of various single fats/oil (olive oil, fish oil or butter) gavaging either in active or passive phase were investigated in rats. Fat/oil gavaged in the active phase of circadian rhythm resulted in higher postprandial serum triglyceride levels compared to that in the passive phase. Moreover, olive oil led to higher MTP activity and apo B-48 gene expression, while fish oil gavaging caused more prominent apo B-48 and MTP gene expression when they were given in the passive phase. The present results indicate that circadian time at which fat or oil gavaged once might exert influence on postprandial lipoprotein synthesis/assembly.