Spray dried nanospheres for inclusion complexes of cefpodoxime proxetil with beta-cyclodextrin, 2-hydroxypopyl-beta-cyclodextrin and methyl-beta-cyclodextrin: improved dissolution and enhanced antibacterial activity

YURTDAŞ KIRIMLIOĞLU G.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol.47, no.8, pp.1261-1278, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 8
  • Publication Date: 2021
  • Doi Number: 10.1080/03639045.2021.1989452
  • Journal Name: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1261-1278
  • Keywords: Cefpodoxime proxetil, 2-hydroxypropyl-beta-cyclodextrin, methyl-beta-cyclodextrin, inclusion complex, antibacterial activity, dissolution, solubility, spray drying, hard cellulose capsules, DRUG-DELIVERY SYSTEMS, IN-VITRO EVALUATION, PHYSICOCHEMICAL CHARACTERIZATION, ANTIMICROBIAL ACTIVITY, AQUEOUS-SOLUTION, 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN PREPARATION, POLYMERIC NANOPARTICLES, BINDING BEHAVIORS, VIVO EVALUATION, CD PREPARATION
  • Anadolu University Affiliated: Yes

Abstract

Objective: The aim of the current research was the development hard cellulose capsules containing cefpodoxime proxetil (CEF) (BCS-Class II) encapsulated nanospheres of inclusion complexes with beta-CD, HP-beta-CD and M-beta-CD for efficient antibacterial therapy.