Spray dried nanospheres for inclusion complexes of cefpodoxime proxetil with beta-cyclodextrin, 2-hydroxypopyl-beta-cyclodextrin and methyl-beta-cyclodextrin: improved dissolution and enhanced antibacterial activity

YURTDAŞ KIRIMLIOĞLU G.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, cilt.47, sa.8, ss.1261-1278, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 8
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/03639045.2021.1989452
  • Dergi Adı: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1261-1278
  • Anahtar Kelimeler: Cefpodoxime proxetil, 2-hydroxypropyl-beta-cyclodextrin, methyl-beta-cyclodextrin, inclusion complex, antibacterial activity, dissolution, solubility, spray drying, hard cellulose capsules, DRUG-DELIVERY SYSTEMS, IN-VITRO EVALUATION, PHYSICOCHEMICAL CHARACTERIZATION, ANTIMICROBIAL ACTIVITY, AQUEOUS-SOLUTION, 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN PREPARATION, POLYMERIC NANOPARTICLES, BINDING BEHAVIORS, VIVO EVALUATION, CD PREPARATION
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objective: The aim of the current research was the development hard cellulose capsules containing cefpodoxime proxetil (CEF) (BCS-Class II) encapsulated nanospheres of inclusion complexes with beta-CD, HP-beta-CD and M-beta-CD for efficient antibacterial therapy.