Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives containing (benz)azole moiety
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.29, no.2, pp.175-184, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 29 Issue: 2
- Publication Date: 2014
- Doi Number: 10.3109/14756366.2013.763253
- Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.175-184
- Keywords: A549, anticancer activity, benz(azole), C6, thiazole, BENZIMIDAZOLE DERIVATIVES, ANTIPROLIFERATIVE ACTIVITY, BIOLOGICAL EVALUATION, DNA-BINDING, AGENTS, ANTITUMOR, THIAZOLE, TIAZOFURIN, BENZOXAZOLES, DOXORUBICIN
- Anadolu University Affiliated: Yes
Abstract
A new class of novel thiazole-(benz) azole derivatives was synthesized to investigate their anticancer activity. The structure of the compounds was confirmed by IR, H-1-NMR, and MS spectral data and elemental analyses. Anticancer effect of the compounds was evaluated against A549 and C6 tumor cell lines. MTT, analysis of DNA synthesis, acridine orange/ethidium bromide staining method and analysis of caspase-3 activation assays were performed for anticancer activity investigations. Compounds 6f and 6g, which carry 5-chloro and 5-methylbenzimidazole groups showed significant anticancer activity. Potential of these compounds to direct tumor cells to apoptotic pathway, which is a precondition of anticancer action, was also observed.