Exploring the Correlation between Ibuprofen Solubility and Permeability in Intestinal Disease Conditions

Kaynak M. S., Soyseven M., Kaval B., Çelebier M., Akgeyik E., Şahin S., ...Daha Fazla

ACTA PHARMACEUTICA SCIENCIA, cilt.62, sa.3, ss.593-609, 2024 (Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.23893/1307-2080.aps6238
  • Dergi Adı: ACTA PHARMACEUTICA SCIENCIA
  • Derginin Tarandığı İndeksler: Scopus, EMBASE
  • Sayfa Sayıları: ss.593-609
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study, physicochemical properties of Ibuprofen were evaluated using HPLC-DAD system to examine the effect of pH on the solubility and intestinal permeability of Ibuprofen. Ibuprofen is still one of the most used and safest non-selective NSAIDs among those approved. Ibuprofen solubility is dramatically affected by pH changes. There is not enough data to show if pH dependent water solubility of ibuprofen will affect its absorption/bioavailability. For this purpose, lipophilicity parameters (logkw) of ibuprofen were determined at various pH ranges using HPLC-DAD system and the results were compared with invivo intestinal permeability results obtained where a perfusion medium having different pH values used (pH 3.9, 4.9 and pH 7.4). The results confirmed that the acidic pH of the perfusion medium increased the permeability of ibuprofen, but in basic pH values (pH 7.4) the permeability was relatively lower. The permeability results were in correlation with determined lipophilicity.